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Original Article
Growth Promoting Effect of Recombinant methionyl-Growth Hormone in Children with Chronic Renal Failure
Heon Seok Han, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1992;35(10):1355-1360.   Published online October 15, 1992
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose...
Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency
Seung Ryul Lee, Ho Seong Kim, Duk Hi Kim, Chang Mi Kim
Clin Exp Pediatr. 1992;35(5):595-601.   Published online May 15, 1992
Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows. 1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg. 2) The GH level of complete GH deficiency...
The Pharmacokinetics and Biological Effects of Yeat Dervied Recombinant Methionyl Growth Hormone in growth Hormone Deficient Children
Byung Churl Lee
Clin Exp Pediatr. 1992;35(3):349-354.   Published online March 15, 1992
The parmacokinetics and biological effects of an recombinant methionyl growth hormone(LBD-003) produced by the expression of genomic hGH in a yeast cell line, were studied in growth hormone deficient children. Twelve patients were randomly assigned to two age-matched subcutaneous and intramuscular groups. Each group consists of 6 patients. Each subject received an dosage of 0.1 U hGH(LBD-003)/kg, BW, Blood was drawn before...
The Effects of Testosterone on the Pituitary Growth Hormone Secretion
Ho Seong Kim, Duk Hi Kim, Kyung Za Ryu, Chang Mee Kim, Deok Bae Park
Clin Exp Pediatr. 1992;35(2):174-181.   Published online February 15, 1992
The effects of testosterone on growth hormone secretion and somatic growth have been reported in several previous studies. In order to investigate the role of testosterone in growth hormone secretion, we have studied the effect of testosterone on somatic growth, basal growth hormone concentration, and growth hormone response to growth hormone-releasing hormone (GHRH) in orchiectomized rats. In experiment 1, four groups...
Effects of sex hormone on secretion of growth hormone.
Bo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(12):1621-1628.   Published online December 31, 1991
Sex honnone had been thought to influence in the serum level of growth honnone (GH) since 1944 year. After it became known that the exogenous administration of sex honnone to growth-retarded children increase serum GH level, sex honnone-especially testosterone-was thought to induce GH release. Testosterone is thought to act on the hypothalamo-pituitary axis to stimulate GH secretion and estradi이 is also thought...
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
Clinical effects of recombinant Korean growth hormone (LBD-003).
Duk Hi Kim
Clin Exp Pediatr. 1991;34(8):1110-1115.   Published online August 31, 1991
LBD-003, methionyl GH, has been produced recently in the yeast by the use of recombinant method. The clinical efficacy and immunogenecity of LBD-003 were studied in 20 patients with naive GH deficiency. The subjects of this study were aged 5.1—13.9 years and received GH 1.5IU/kg thrice weekly for 1 year. During treatment, height, body weight & bone age were checked. Blood count, chemistry amd thyroid...
The effects of human growth hormone on short stature.
Sang Mi Ha, Duk Hi Kim
Clin Exp Pediatr. 1991;34(7):999-1008.   Published online July 31, 1991
Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies of its usefulness in short stature. The availability of a biologically active human growth hormone produced by recombinant-DNA technology has dramatically changed the...
The mechanism of Arginine-stimulated growth hormone secretion.
Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(4):544-552.   Published online April 30, 1991
Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on GH secretion in GH deficient short stature patient and constitutional growth delay. The results of the studies were as follows: 1) Peak...
Clinical effects of yeast derived recombinant methionyl growth hormone in growth hormone deficiency.
Byung Churl Lee
Clin Exp Pediatr. 1991;34(3):334-339.   Published online March 31, 1991
Since the success of human growth hormone (hGH) synthesis by recombinant DNA technology, these GH products are used in the treatment of growth hormone deficiency. Recently, methionyl-GH has been produced in the yeast, Saccharomyces cerevisiae 2150 by the use of a recombinant method. In this paper, the clinical efficacy and. immunogenicity of this GH was studied during therapy of 1 year in 20 children...
The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones.
Jong Jin Seo
Clin Exp Pediatr. 1990;33(8):1104-1110.   Published online August 31, 1990
The pharmacokinetics, acute biological성fccts and safety of yeast-derived recombinant methionyl- hGH (LBD-003), the first biosynthetic hGH in Korea, were studied in 10 healthy young adults who were administered 8 IU/day intramuscularly for four consecutive days. 1) GH levels reached a mean (±SD) peak of 27.5±10.7 ng/ml at 3.4±0.8 hours following the first dose, and other pharmacokinetic parameters of LBD-003 were similar to those reported for pituitary...
Clinical Study on Growth Hormone Deficient Dwarfs.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(5):597-606.   Published online May 31, 1988
34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old and bone age was delayed with average 6.6 years old. The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma, germinoma & Tb. meningitis were relatively uncommon. Cerebral anoxia seemed...
The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
Duk Hi Kim, Chan Il Park
Clin Exp Pediatr. 1988;31(1):64-71.   Published online January 31, 1988
Growth hormone and thyroid hormone are known to affect growth and development. The present experiment was undertaken to assess GH levels in the serum and pituitary gland of prophylthiouracil (PTU) treated rats. The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU, their levels were recovered gradually. Acidophil...
A Study on Serum Growth Hormone in DM of Childhood.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(2):175-180.   Published online February 28, 1987
The human growth hormone (hGH) levels were evaluated in 13 diabetes mellitus, 11 patients were insulin dependent diabetes (ages 2 yr 10 mo to 13 yr 14 mo), 2 patients were noninsulin dependent diabetes (age 12 yr & 12 yr 5 mo). No difference in hGH level was observed in relation to duration of diabetes. The hGH responses to glucagon 1 mg injection in...
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